When Screening for Severe Combined Immunodeficiency (SCID) with T Cell Receptor Excision Circles Is Not SCID: a Case-Based Review
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چکیده
منابع مشابه
Newborn screening for severe combined immunodeficiency (SCID): a review.
Because prompt intervention may prevent complications, early diagnosis is important in many inherited metabolic diseases. Early diagnosis of Severe Combined Immunodeficiency (SCID) is critical - because chances for successful treatment are highest for infants who have not yet experienced severe opportunistic infections. SCID is a rare disease that can be detected in newborn infants (i.e., those...
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High Throughput Newborn Screening for Severe Combined Immunodeficiency (SCID) Using the Automated T-cell Receptor Excision Circle (TREC) in situ Assay R. Haughton, S. Dever, K. Turner, L. Hancock, J. Taylor, Golriz Yazdanpanah, F. Lee; Virginia Division of Consolidated Laboratory Services, Richmond, VA, Centers for Disease Control and Prevention, Atlanta, GA, RTI International, Research Triangl...
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To characterize thymic epithelial cells of SCID (severe combined immunodeficiency) mice in comparison with those of Balb C mice, we did an immunohistochemical study using cortical and medullary epithelial cell specific monoclonal antibodies (MoAbs), Th-3 and Th-4, as well as gel electrophoresis and immunoblotting. The thymi of SCID mice were composed of epithelial cells and a few lymphocytes. M...
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Early detection of severe combined immunodeficiency (SCID) followed by prompt treatment is critical for affected babies to live healthy lives. Newborn screening (NBS) for SCID using the T-cell receptor excision circle (TREC) test has been being performed in California for two years and around 1 million babies have been screened there. The test has demonstrated high specificity and sensitivity i...
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Severe combined immunodeficiency is a rare, fatal syndrome of diverse genetic cause in which there is combined absence of T-lymphocyte and B-lymphocyte function (and in many cases also natural killer, or NK lymphocyte function). These defects lead to extreme susceptibility to serious infections. Without intervention, the T and B-cell dysfunction usually results in severe infection and death in ...
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ژورنال
عنوان ژورنال: Journal of Clinical Immunology
سال: 2021
ISSN: 0271-9142,1573-2592
DOI: 10.1007/s10875-020-00931-2